Thurday 6:00 Welcome Reception, Brickyard Restraurant and Sports Pub
9:00Flow Cytometry and Its Role in Anatomic Pathology Dr. Sharon Swierczynski – Reading Hospital
Flow cytometric analysis is a powerful laboratory technique whereby cells can be categorized according to their size, cytoplasmic complexity, and antigen expression. To date, flow cytometry is used most commonly in clinical anatomic pathology as an adjunct to the diagnosis of hematologic malignancies. Flow cytometry can be applied to fresh lymph node specimens, bone marrow aspirates, cytopathology body fluids and fine needle aspirates, as well as any fresh tissue suspected of harboring a hematologic malignancy. The Pathologist’s Assistant plays an important role in facilitating this technique by being aware of its utility and recognizing specimens appropriate for its use.
This presentation will focus on the basic operational principles of flow cytometric analysis and the application of flow to the diagnosis of lymphomas and leukemias.
10:15The Clinic for Special Children and the practice of translational medicine Kevin A. Strauss, M.D. - Clinic for Special Children, Strasburg, Pennsylvania The Clinic for Special Children was established in 1989 as a non-profit medical service for Amish and Mennonite children with genetic disorders. The Clinic provides medical services for over 800 pediatric patients representing more than 80 genetic disorders. It serves children from the Plain communities by translating advances in basic research into timely diagnoses and accessible, comprehensive medical care. Through early diagnosis and a system of comprehensive care, we prevent problems like mental retardation, brain degeneration, lethal infection, and untimely death.
The close association between our clinical and research staff provides effective and economical medical care as well as opportunities to understand relationships among genes, environment, and disease. The identification of underlying molecular lesions alone rarely provides insight into disease complications and their appropriate treatment.Indeed, many facets of genetic disorders only become known through solving clinical problems.Pathological investigations play a pivotal role in this process, and the histological methods used are adapted to the problem under study.Our integrated, “small science” approach to genetic problem-solving yields large benefits to our patients and their families. Our work demonstrates that the everyday practice of clinical and laboratory medicine has wide biological relevance, and constitutes the true frontier of translational genetics.
12:45Phlashback to renal Physiology and Diabetes Mellitus Janine Riben, PA (ASCP) – York Hospital
Renal physiology is a topic that we all learned during our training and quickly forgot (at least I can speak for myself)!It is important though, since statistics show that the number of people with chronic kidney disease is on the rise – currently, 20 million Americans have some degree of chronic kidney disease.The presentation is twofold.The first part consists of a review of basic renal physiology.The second part examines the pathologic changes in Diabetic Kidney Disease.The information in this lecture will aid in understanding another MAPA lecture entitled “Early Detection of Chronic Kidney Disease”.
2:00Early Detection of Chronic Kidney Disease Stephen Manzella, Ph.D. – York Hospital
It is estimated that 10-20 million people in the U.S. have chronic kidney disease (CKD) as defined by a glomerular filtration rate (GFR) of less than 60 ml/min/1.73 m2 or persistent albuminurea (>30 mg urinary albumin/g uninary creatinine).CKD may go unrecognized in at-risk patients (i.e., diabetes, hypertension, cardiovascular disease, or family history of kidney disease) and progress to kidney failure without effective treatment.This has precipitated the need for a greater effort, as outlined by the National Kidney Foundation, to educate clinicians about screening for CKD. This presentation will address the role that simple laboratory tests play in defining, staging and early detection of CKD, also deal with the benefits and limitations of these clinical laboratory tests and introduce potential future biomarkers for CKD.
9:00A Small, but NOT Boring Hospital Dr.Michael Young – Heart of Lancaster Regional Medical Center
Pathologists and pathologists’ assistants working at small community hospitals do not expect to face the flood of interesting and complex cases seen daily at larger hospitals and tertiary centers, but nonetheless can encounter challenging and unusual cases.An assortment of of patients with uncommon epithelial and mesenchymal tumors, as well as rare disorders such as delusional parasitosis, will be presented.
10:15Ductal Carcinoma in Situ of the Breast Michelle Rosenow PA (ASCP) – DeKalb Medical Center, Alpharetta, GA
This lecture will discuss DCIS of the breast focusing on
12:45Current Issues in Breast Pathology Dr. Ronald Grenko - Lancaster General Hospital
This talk will address three current issues in breast pathology:
1.Review of the CAP/ASCO guidelines for handling of breast specimens and a group discussion of challenges and solutions for applying the guidelines.
2.A discussion of classification of breast cancers with emphasis on new entities and a look forward toward possible new classifications
3.Discussion of molecular profiling of cancers and how that influences therapeutic choices.
2:00Cytopathology for the Pathologists’ Assistant:An emphasis on intraoperative cytologic evaluation. Dr. Debra Grove-Mahoney - Lancaster General Hospital
The purpose of this presentation is to discuss the role of cytologic interpretation in the frozen section arena, as well as, the appropriate techniques for preparing these specimens.The advantages and disadvantages to the addition of or choice of intraoperative cytology.
A discussion of classification of breast cancers with emphasis on new entities and will be considered.The workshop will conclude with a “hands on” opportunity to practice smear/ touch prep techniques